Our laboratory studies the fundamental mechanisms underlying craniofacial development. Disruption of this process often leads to craniofacial defect, one of most common birth defects. Using a combination of multifaceted experimental approaches, we are engaged to illustrate how craniofacial morphogenesis is regulated at the cellular and molecular level. Our long term goal is to reveal the etiologies of craniofacial defect, and ultimately to reduce its occurrence in human.